San Luis, Arizona: A Gateway for Economic Growth. Nestled on the U.S. - Mexico border alongside its sister city, San Luis Río Colorado, San Luis, Arizona, is a thriving hub of opportunity. With a strong economic base in professional services, retail, agribusiness, and light industry, San Luis continues to grow while maintaining its welcoming, family - oriented atmosphere and low cost of living. The city boasts affordable housing, excellent educational opportunities, and vibrant recreational spaces, making it a great place to live and work. San Luis is also a key player in international trade, with two state - of - the - art Ports of Entry facilitating efficient commercial and pedestrian traffic. The city ’ s industrial expansion includes new parks and facilities linked to the Area Service Highway, enabling seamless access to Interstate 8. As a center for agriculture and a growing industrial hub, San Luis is poised for continued economic success, providing businesses with the infrastructure and community support needed to thrive.